Activation Outcomes Induced in Naïve CD8 T-Cells by Macrophages Primed via “Phagocytic” and Nonphagocytic Pathways. ... Rock K. L. Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate, develop effector function, and differentiate into memory cells. J. Immunol.
The attributes of specificity and memory enable CD8+ T cells to provide long-lasting protection against a variety of challenges. fate, Adoptive cell transfer and tumor immunity Introduction CD8+ T cells are an essential part of the adaptive immune system that control contamination by intracellular pathogens and malignant change [1, 2].
Virus-specific CD8 + T cells develop the ability to function in an “innate” capacity by responding to a remarkable array of cytokines in a TCR-independent manner. Although several cytokines such as IL-12 and IL-18 have been identified as key regulators of CD8 + T-cell activation, the role of other cytokines and the ways in which they interact with each other remain unclear.
The CXCR5/CXCL13 pair by means of activation of APRIL (A proliferation-inducing ligand) induced resistance to apoptosis in T-ALL CD8+CD34+ T cells in livin-dependent manner. In this process, cell ...
CD4 and CD8 T cells are an important part of the host’s capacity to defend itself against viral infections. During flavivirus infections, T cells have been implicated in both protective and pathogenic responses. Given the recent emergence of Zika virus (ZIKV) as a prominent global health threat, the question remains as to how T cells contribute to anti-ZIKV immunity.
Stimulation of Naive CD8+ T Cells by a Variant Viral Epitope Induces Activation and Enhanced Apoptosis ... our results show that VLP vaccine-induced CD8 T cell-mediated protection is not limited ...
Primary macrophages modulate antigen cross-presentation and T-cell activation. We assessed ex vivo the putative role of different phagocytic receptors in immune synapse formation with CD8 naïve T-cells from OT-I transgenic mice and compared this with the administration of antigen as a soluble peptide.
Introduction CD8+ T cells play an important role in combating many primary virus infections, ... The simultaneous activation of many host T cells can have potentially as ...
DNA methylation was assessed at 450,000 genomic sites in CD4+ and CD8+ T cells purified from peripheral blood of 94 women with MS and 94 healthy women, and differentially methylated regions were identified using bumphunter. Differential DNA methylation was observed near four loci: MOG/ZFP57, HLA-DRB1, NINJ2/LOC100049716, and SLFN12.
Purpose: To evaluate whether patients with metastatic gastrointestinal adenocarcinomas refractory to chemotherapy harbor tumor-reactive cytotoxic T cells. Experimental Design: Expansion of CD8+ tumor-infiltrating lymphocytes (TIL) and cancer cell lines was attempted from gastrointestinal cancer metastases in 16 consecutive patients for the study of antitumor immune recognition.
Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells: 更多... PLOS ONE 2012 . Human Macrophages and Dendritic Cells Can Equally Present MART-1 Antigen to CD8+ T Cells after Phagocytosis of Gamma-Irradiated Melanoma Cells. DOI: 10.1371/journal.pone.0040311.
Given the protective roles of 25-hydroxyvitamin D (25(OH)D or vitamin D) in musculoskeletal health and the potential beneficial effects of vitamin D supplementation in reducing the risk of various chronic diseases, intensive repletion of vitamin D has been widely advocated. Of note, CD8 T cells have the highest levels of the vitamin D receptor compared with other major immune cells.
Although na€ ve TRP1low CD8 T cells do not affect tumor growth, upon activation these cells function indistinguishably from TRP1high cells in vivo, limiting tumor cell growth and increasing mouse survival. The antitumor effect of both TRP1high and TRP1low CD8 T cells is enhanced in RAG-deﬁcient hosts.
Comparative analysis of transcriptional profiling of CD3+, CD4+ and CD8+ T cells identifies novel immune response players in T-Cell activation: High CD8+ T Cell Activation Marks a Less Differentiated HIV-1 Specific CD8+ T Cell Response that Is Not Altered by Suppression of Viral Replication
Liu et al. find that tumor-repopulating cells (TRCs) regulate PD-1 expression in CD8+ T cells. TRCs secrete kynurenine that is taken up by T cells and activates AhR, which directly regulates PD-1 expression. Blockade of this pathway enhances adoptive T cell therapy efficacy in a mouse melanoma model.
Ifng and Cxcr3 were all induced in immunized CD8þ T cells relative to those in na€ve T cells (Fig. 1B). These genes were not highly expressed in tolerant T cells, but checkpoint blockade treatment of Alb:Gag recipients resulted in increased expression ofTbx21,Ifng,andCxcr3.Unexpectedly,Eomeswasnotaffectedby this same blockade treatment.
Activation Outcomes Induced in Na ̈ve CD8 T-Cells by Macrophages Primed via “Phagocytic” and Nonphagocytic Pathways Article (PDF Available) in Molecular biology of the cell 19(2):701-10 ...
However, because of the physical separation from the sinusoids, hepatic DCs are unlikely to activate naive T cells in the liver. It is more likely that these professional APCs undergo maturation and migrate to the liver-draining LNs to mediate T cell activation. CD8 T cells activated within the liver are rendered tolerant via several mechanisms.
Activation Outcomes Induced in NaÄ±ve CD8 T-Cells by Macrophages ... Recommend Documents. Activation Outcomes Induced in NaÄ±ve CD8 T-Cells by Macrophages ... restricted anti-OVA TCR transgenic line under a C57BL/6 background, were ... added to macrophages at an approximate BSA or OVA protein concentration.